Error parsing XSLT file: \xslt\Head/MetaTags.xslt
This website uses cookies

This websites contains videos from YouTube. This company uses cookies (third party cookies). If you do not want them to use these cookies, you can indicate so here. However, this does mean that you will not be able to watch videos on this website. We also make use of our own cookies in order to improve our website. We don't share our data with other parties. Which cookies are involved?

This website uses cookies to enable video and to improve the user experience. If you do not want to accept these cookies, indicate so here. Which cookies are involved?

Ga direct naar de inhoud, het hoofdmenu, het servicemenu of het zoekveld.

Surgical Oncology:

Theo Ruers

Prof. dr. Theo JM RuersSurgeon, Professor

About Theo Ruers

During surgery, tumor tissue is often difficult to identify. As a consequence, the surgeon can have difficulties with deciding which tissue should be removed and which tissue can be spared. If tumor tissue is left in the patient during surgery, a patient requires additional treatment after surgery. On the other hand, when healthy tissue is removed unnecessary this can cause avoidable morbidity and poor cosmetic result.

At the NKI-AvL, we developed and implemented a concept called image-guided surgery to improve surgical outcome in oncology. This innovative approach is concentrated around the three sequential steps within the surgical workflow:

Tumor localization

A surgical electromagnetic navigation system guides the surgeon with high accuracy towards the location of the tumor tissue, while visualizing vital structures around the tumor. This allows the surgeon to find the tumor avoiding damage to critical structures.

Tumor treatment (surgical resection)

Smart surgical instruments with integrated optical technology in the tip of the instruments are used to characterize the tissue around the tumor. This enables to discriminate healthy tissue from tumor tissue in areas where the surgeon is unsure about the nature of the tissue.

Assessment of tumor treatment

Directly after tumor resection, the tissue is assessed with hyperspectral and multispectral cameras in the operation room. This to ensure that the margins of the resected tissue are free of tumor. If tumor tissue is present at the margin of the removed tissue, an additional resection can performed immediately.

These technologies have been successfully translated - in close collaboration with Technical University Twente and commercial partners - from bench to bedside. Some techniques are currently introduced into the surgical workflow, while others are being evaluated within a broad range of surgical procedures and tested for efficacy and cost-effectiveness. 

Image Guided Surgery group

For more information about the image guide surgery group, click here.

Research projects

There are numerous research projects available for students, all aimed to tackle the described shortcomings in cancer surgery by the application of image guidance:

Surgical navigation projects

Optical imaging projects

Co-workers

Dick Sterenborg

Dick Sterenborg

Professor

Experience

Dick (H.J.C.M.) Sterenborg received a M.Sc. in Applied Physics from the University of Eindhoven, The Netherlands in 1982 and he has been active in Biomedical Optics Research since then. From 1988 to 1998 he was a staff member of the Medical Laser Centre of the Academic medical Centre in Amsterdam. In 1998 he moved to the Erasmus Medical Center and (co)founded the Centre for Optical Diagnostics and Therapy and 2008 he was appointed Professor of Photodynamic Therapy at the Erasmus University. Since 2013 he is back in Amsterdam where he has a joint position at the department of Biomedical Engineering and Physics of the Academic Medical Centre in Amsterdam and the Surgical Innovations Group at the Netherlands Cancer Institute. His main focus of research is currently Elastic Scattering Spectroscopy and Hyperspectral Imaging.

Close this window
Koert Kuhlmann

Dr. K.F.D. (Koert) Kuhlmann

Surgeon

Experience

Sinds 2012 ben ik werkzaam als chirurg in het Antoni van Leeuwenhoek. Ik ben gespecialiseerd in de chirurgische behandeling van darmkanker en uitzaaiingen naar de lever. Middels een beurs van het Koningin Wilhelmina Fonds heb ik twee jaar kunnen werken in de beste ziekenhuizen ter wereld op het gebied van leverchirurgie. Door de ervaring die ik heb opgedaan in Liverpool, New York, Parijs en Los Angeles ben ik op de hoogte van alle mogelijke behandelopties voor tumoren van de lever. Het grootste deel hiervan kunnen we in het Antoni van Leeuwenhoek aan onze patiënten aanbieden.

Naast mijn klinische taken houd ik me intensief bezig met de ontwikkeling van een chirurgisch navigatiesysteem (een soort TomTom) dat de chirurg tijdens de operatie kan gebruiken. Ik doe ook onderzoek naar de behandeling van uitzaaiingen van darmkanker naar de lever.

De hoge mate van expertise binnen ons ziekenhuis, de multidisciplinaire zorg en het doen van basaal en toegepast onderzoek naar kanker maken ons ziekenhuis uniek. Mijn patienten kunnen rekenen op een zorgvuldig gekozen behandeling op maat en persoonlijke aandacht en tijd.

Close this window
Harald Groen

Harald Groen

Post doc

Personal details

Groups

Experience

As a biomedical engineer, I'm working in a clinical implementation team on image image-guided surgery. In collaboration with surgeons, research groups and industrial partners new imaging modalities and surgical navigation methods for complex procedures are being developed and applied.

I obtained my PhD at the Erasmus MC, Rotterdam on the role of shear stress in atherosclerotic plaque rupture in human carotid arteries, followed by a post-doc period at the nuclear medicine department. Then I moved to the industry for 5 years as an application and sales scientist for micro PET/SPECT/CT systems.

Close this window
van Veen, Ruben

Ruben van Veen

Post doc

Experience

During my technical medicine masters I specialized in medical imaging and interventions. Going through my clinical rotations in the AMC, Meander MC, St. Antonius and NKI, I developed a special interest for the surgical field. I am passionate about the use of modern techniques to improve surgical outcome.

After two years of research on early detection of complications after endovascular aortic repair I returned to the NKI in 2017. Here in the NKI I work with researchers and surgeons on the development and implementation of image guided navigation during complex surgical procedures.

Close this window
Fusaglia

Matteo Fusaglia

Post doc

Experience

I obtained the PhD in biomedical Engineering at the University of Bern, Switzerland, where I worked on surgical navigation for laparoscopic liver surgery. Within this context, I developed an image-guidance system that provides augmented reality between the surgical scene and preoperative 3D anatomical models. This system was validated in several procedures, including robotic navigation. Currently I am employed at the Netherlands Cancer Institute where I continue working on surgical navigation and where I am developing a navigation system based on head-mounted display.

Close this window
Post, Anouk

Anouk Post

Post doc

Experience

Anouk Post received an MSc. in Physics with the specialization Physics of Life and Health, at the University of Amsterdam in the Netherlands, in 2013. As part of her master degree, she did research at Imperial College in London for one year, where she developed software to produce 3D Optical Coherence Tomography (OCT) images of blood vessels and used this to study the influence of shear stress on plaque formation. Since June 2014 Anouk is a Ph.D. candidate at the Academic Medical Center in Amsterdam, where her research focuses on the combination of OCT and Spectroscopy as a diagnostic tool for cancer. Since 2018, Anouk has a joint position at the  Academic Medical Centre and the Surgical Innovations Group at the Netherlands Cancer Institute. The main focus of her research is the development of optical techniques (using light) to improve cancer detection.

Close this window
Behdad Dasht Bozorg

Behdad Dasht Bozorg

Post doc

Experience

Behdad received his M.Sc. from Yazd University, Iran, and his Ph.D. in Electrical Engineering from the University of Porto, Portugal, in 2015. From 2015 to 2018 he was a postdoctoral researcher in the group of Medical Image Analysis, at the Department of Biomedical Engineering, Eindhoven University of Technology (TU/e). Since 2018, Behdad joined the NKI and his main focus of research is currently image-guided treatment. His research interests include medical image analysis, image processing, machine learning and computer vision.

Close this window
0

Wout Heerink

Post doc

Experience

Postdoc Image-guided Surgery

Close this window
Lisanne de Boer

Lisanne de Boer

Post doc

Experience

I graduated in the master track Robotics & Imaging in 2013 at the University Twente. After receiving my master degree I proceeded my graduation project with a PhD-position. My research focuses on the use of Diffuse Reflectance Spectroscopy (DRS) for the detection of positive resection margins during breast conserving surgery. Because surgeons cannot always see or feel the tumor during surgery, some breast cancer patients need additional therapy for the left behind tumor. DRS is a light based technology that allows to discriminate normal tissue from tumor tissue based on light-tissue interactions. The aim is to detect the positive resection margins with intra-operative DRS measurements and provide this information to the surgeon, thereby avoiding additional treatment. 

Close this window
Nikie Hoetjes

Nikie Hoetjes

Research assistant

Personal details

Groups

Experience

My name is Nikie Hoetjes and I am the research assistant/ data manager of the clinical implementation team for image guided surgery.  I am responsible for the patient logistics, which means the following; patient inclusion, logistics, practical assistance during surgical procedures, and collection of data.

Close this window
Profielfoto Susan 001

Susan Brouwer de Koning

Ph.D. Student

Experience

I graduated from my studies in Technical Medicine (University of Twente) in early 2016, with a special interest in medical imaging and interventions. During my graduation project at Guy's Hospital, London, I validated a device to evaluate tumor margins during breast-conserving surgery. Due to my interest in intra-operative imaging technologies, I began working at the NKI as a PhD student and as a member of the Clinical Implementation Team, responsible for the implementation of new technologies in the operation room. At the moment I am researching the potential for diffuse reflectance spectroscopy to assess tumor margins intra-operatively.

Close this window
Roeland Eppenga

Roeland Eppenga

Ph.D. Student

Experience

In 2008 I got my Master's degree in Biomedical Engineering at the Twente University, after finishing my Master's thesis on motion artifacts in gait analysis using inertial sensors. After my graduation I started working at the Saint Antonius Hospital in Nieuwegein, providing technical support to the OR and IC while being a coordinator of a medical technical team. At the end of 2011 I decided to fully focus on product development and started working via recruitment agency YACHT in High Tech Eindhoven. I worked for ASML, Philips , VDL ETG and DAF as a LabVIEW and Simulink software engineer and mechatronics test engineer. After these interesting four years I wanted to go back to academic medical research and finally found that opportunity in my current PhD position here at the NKI-AvL, which is about navigation for mobile tumors. 

Close this window
Esther Kho

Esther Kho

Ph.D. Student

Personal details

Groups

Experience

In 2014, I received my Master's degree Biomedical Engineering, with specialization Clinical Physics, from the University of Groningen. Since 2015, I have been working towards the Ph.D. degree at the NKI-AvL. My research concerns the development, testing and clinical evaluation of a hyperspectral imaging system. This technique has already been used for various application by NASA  but was only recently introduced in the medical field. With hyperspectral imaging, we are able to see tumorous tissue in healthy tissue. This is of major importance during breast conserving surgeries, where the surgeon aims to only remove the tumor and preserve as much surrounding healthy tissue. By using hyperspectral imaging, we will be able to help the surgeon, during the operation, to see weather indeed the whole tumor has been removed. This prevents incomplete tumor removal and therefore avoids additional treatment.

Close this window
Baltussen, Lisanne2

Lisanne Baltussen

Ph.D. Student

Experience

In 2014 I received my Master's degree of the study Technical Medicine in Enschede. My graduation project focused on navigation during laparoscopic colorectal surgery and was a co-operation between the surgical department in the NKI and Philips. Currently I'm working as a PhD student on the subject of diffuse reflectance spectroscopy during colorectal surgery. This can be used to prevent positive resection margins and postoperative complications.   

Close this window
Esther Kok

Esther Kok

Ph.D. Student

Experience

In June 2017 I graduated from medical school at the Vrije Universiteit in Amsterdam. I did my last internship at the surgery department in the NKI-AvL and was happy to get the opportunity to proceed my research after I finished university. Now, while performing a Ph.D. at the Surgical Oncology department, my medical doctor background gives me the possibility to look from a different perspective on ongoing projects in the group. In my research, I focus on the testing and implementing of hyperspectral imaging in treatment of patients with colorectal cancer. Besides that, I'm working on multiple clinical studies to optimize treatment in patients with colorectal cancer with liver metastases. These projects give me the opportunity to work in a multi-disciplinary team, which I enjoy a lot.

Close this window
Jasper Smit

Jasper Smit

Ph.D. Student

Experience

In september 2017, I got my Master´s degree in Technical Medicine at the University of Twente. After four clinical rotation internships in different hospitals, I did my graduation internship at the surgery department of the NKI-AVL with interests for oncology and image-guided surgery. The work was focused on the feasibility of ultrasound-guided navigation for liver lesions. Right now, this is the subject of my PhD project in the clinical implementation team with the goal to improve the surgical resection and ablation of lesions in the liver with ultrasound-guided navigation.

Close this window
Geldof

Freija Geldof

Ph.D. Student

Experience

In 2018 I graduated from the Master Technical Medicine at the University of Twente, with a specialization in the direction of medical imaging and interventions. During my Master's program I performed multiple internships in different hospitals and that's when I developed a strong interest in the surgical departments.

After my graduation project at the department of surgical oncology at the NKI, that was focused on surgical navigation in head and neck surgery, I continued working as a PhD student in Theo Ruers' group. In my current research project I am working on combining optical techniques with ultrasound and navigation technologies to develop a real-time tissue discrimination tool that can provide guidance during oncological surgery.

Close this window
Foto NKI LS Jong

Lynn-Jade Jong

Ph.D. Student

Experience

In 2019 I graduated from the University of Technology in Delft with a Master's degree in Biomedical Engineering. During my studies I conducted research at the Amsterdam UMC, SINTEF Medical Technology and Philips Research. While finalizing my Master's, I became driven to contribute to medical innovations and to overcome current challenges of implementing technology into clinical practice. Now, as a PhD student in Theo Ruers' group, I have the opportunity to closely experience surgical difficulties in oncology and to seek for technical solutions that can be properly translated to the surgeons' perspective and implemented within the surgical workflow.
My current research is focused on the application of hyperspectral imaging during surgery, to enable the surgeon to remove tumorous tissue more accurately and thus to prevent the necessity to perform additional treatment.

Close this window

Research updates View All Updates

  • Clinical Research: targeted abdominal lymph node dissections randomized for surgical navigation

    Prof. Th. J. M. Ruers, Oncological Surgeon

    Start date: January 2017
    Number of patients: 92
    Patient group: Patients (age ≥ 18) planned for removal of at least one target lymph node during abdominal surgery.

    Image-guided navigation surgery allows for full utilization of pre-operative imaging during surgery, and has the potential of reducing both irradical resections and morbidity. In this randomized study, patients which will undergo an abdominal lymph node dissection with our without image guidance in order to evaluate the actual technical and clinical benefit of navigation.

  • Clinical Research: tracking of oral cavity carcinomas in head and neck surgery

    Dr. M.B. Karakullukcu, Head and Neck Surgeon

    Start date: April 2017
    Number of patients: 50
    Patients (age ≥ 18)  who are planned for surgery of tumors fixated to the maxilla or mandible and patients with tongue tumors (tumor size > T1).

    The objective of this study is to evaluate the feasibility and clinical accuracy of an in‐house developed electromagnetic (EM) navigation system in determining adequate resection margins during surgery for malignant oral cavity tumors and specifically tongue tumors.

Key publications View All Publications

  • Prospective study on image‐guided navigation surgery for pelvic malignancies

    J Surg Oncol. 2018 Dec 24

    Nijkamp J, Kuhlmann KFD, Ivashchenko O, Pouw B, Hoetjes N, Lindenberg MA, Aalbers AGJ, Beets GL, van Coevorden F, KoK N, Ruers TJM

    Prospective study on image-guided navigation surgery for pelvic malignancies
  • Real-time wireless tumor tracking during breast conserving surgery.

    Int J Comput Assist Radiol Surg. 2017 Nov 13.

    Janssen NN, Eppenga R, Peeters MJ, van Duijnhoven F, Oldenburg HS, van der Hage J, Rutgers E, Sonke J-J, Kuhlmann K, Ruers T and Nijkamp J

 
 

Recent publications View All Publications

 

Contact

  • Office manager

    Sandra Wagenvoort

  • E-mail

    s.wagenvoort@nki.nl

  • Telephone Number

    +31(0)20 512 2565

Sandra Wagenvoort
Share this page